› 6d4g

X-ray diffraction
2.8Å resolution

N-GTPase domain of p190RhoGAP-A

Released:
DOI: 10.2210/pdb6d4g/pdb
PDB entry 6d4g coloured by chain, front view.
PDB entry 6d4g coloured by chain, side view.
PDB entry 6d4g coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase.
Stiegler AL, Boggon TJ
Structure 26 1451-1461.e4 (2018)
PMID: 30174148

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160479 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho GTPase-activating protein 35 Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 30.63 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P81128 (Residues: 1-266; Coverage: 18%)
Gene names: Arhgap35, Grlf1, P190A, p190ARHOGAP
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand GTP 2 x GTP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 43.69Å b: 69.27Å c: 154.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.25 0.29
Expression system: Escherichia coli

Quick links

Citations

5 review citations

p190RhoGAPs, the ARHGAP35- and ARHGAP5-Encoded Proteins, in Health and Disease.
Héraud et al. (2019)
4 more

2 mentions without citation

The Bombyx mori karyotype and the assignment of linkage groups.
Yoshido et al. (2005)
1 more