X-ray diffraction
3.75Å resolution

Crystal structure of Xenopus Smoothened in complex with cyclopamine


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 612 amino acids
Theoretical weight: 68.98 KDa
Source organisms: Expression system: Spodoptera frugiperda
  • Canonical: P0ABE7 (Residues: 23-127; Coverage: 99%)
  • Canonical: A0A1L8GTP2 (Residues: 35-401, 416-528; Coverage: 61%)
Gene names: XELAEV_18020875mg, cybC
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 145.778Å b: 79.232Å c: 104.076Å
α: 90° β: 108.51° γ: 90°
R R work R free
0.229 0.227 0.26
Expression system: Spodoptera frugiperda