6d2p

X-ray diffraction
2.6Å resolution

Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8 Chain: C
Molecule details ›
Chain: C
Length: 183 amino acids
Theoretical weight: 19.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
IOMAclass naive CLK31 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 221 amino acids
Theoretical weight: 23.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
IOMAclass naive CLK31 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 22.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21212
Unit cell:
a: 134.3Å b: 66.636Å c: 76.518Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.268
Expression system: Homo sapiens