Solution NMR

HADDOCK structure of the Rous sarcoma virus matrix protein (M-domain) in complex with inositol 1,4,5-trisphosphate


Function and Biology Details

Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Endonucleolytic cleavage to 5'-phosphomonoester.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Matrix protein p19 Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 9.21 KDa
Source organism: Rous sarcoma virus - Prague C
Expression system: Escherichia coli
  • Canonical: P03354 (Residues: 2-87; Coverage: 5%)
Gene name: gag-pol
Sequence domains: Retroviral M domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 16%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli