6cs9

X-ray diffraction
1.85Å resolution

Crystal structure of human beta-defensin 2 in complex with PIP2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-defensin 4A Chains: A, B
Molecule details ›
Chains: A, B
Length: 41 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: O15263 (Residues: 24-64; Coverage: 100%)
Gene names: DEFB102, DEFB2, DEFB4, DEFB4A, DEFB4B
Sequence domains: Beta defensin
Structure domains: Antimicrobial Peptide, Beta-defensin 2; Chain A

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 32.871Å b: 25.538Å c: 40.17Å
α: 90° β: 98.64° γ: 90°
R-values:
R R work R free
0.196 0.195 0.227
Expression system: Komagataella pastoris