6cms

X-ray diffraction
2.68Å resolution

Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Padua RAP, Sun Y, Marko I, Pitsawong W, Kern D

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 11 Chain: A
Molecule details ›
Chain: A
Length: 532 amino acids
Theoretical weight: 61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q06124 (Residues: 1-529; Coverage: 89%)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2, SSRL BEAMLINE BL14-1
Unit cell:
a: 40.715Å b: 54.141Å c: 218.847Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.205 0.265
Expression system: Escherichia coli BL21(DE3)