› 6cks

X-ray diffraction
1.72Å resolution

Crystal Structure of BRD4 with QC4956

Released:
DOI: 10.2210/pdb6cks/pdb
PDB 6cks coloured by chain and viewed from the front.
PDB 6cks coloured by chain and viewed from the side.
PDB 6cks coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry author: Hosfield DJ

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 15.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand F5Y 1 x F5Y
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P212121
Unit cell:
a: 41.83Å b: 49.12Å c: 56.673Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.165 0.211
Expression system: Escherichia coli K-12

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