› 6cjl

X-ray diffraction
1.7Å resolution

Candida albicans Hsp90 nucleotide binding domain in complex with radicicol

Released:
DOI: 10.2210/pdb6cjl/pdb
PDB 6cjl coloured by chain and viewed from the front.
PDB 6cjl coloured by chain and viewed from the side.
PDB 6cjl coloured by chain and viewed from the top.
Source organism: Candida albicans SC5314
Entry authors: Nation C, Pizarro JC

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein 90 homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 230 amino acids
Theoretical weight: 26.21 KDa
Source organism: Candida albicans SC5314
Expression system: Escherichia coli
UniProt:
  • Canonical: P46598 (Residues: 7-218; Coverage: 30%)
Gene names: CAALFM_C702030WA, CaJ7.0234, CaO19.13868, CaO19.6515, HSP90
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

2 bound ligands:
Ligand RDC 2 x RDC
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P43
Unit cell:
a: 73.1Å b: 73.1Å c: 109.514Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.145 0.145 0.165
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Emerging Antifungal Targets and Strategies.
Ivanov et al. (2022)
14 more