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Pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica with acetyl-TPP bound

Source organism: Moorella thermoacetica ATCC 39073
Biochemical function: 4 iron, 4 sulfur cluster binding
Biological process: electron transport chain
Cellular component: not assigned

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EC 1.2.7.1: Pyruvate synthase

Reaction catalysed:
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+)
Systematic name:
Pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)
Alternative Name(s):
  • 2-ketobutyrate synthase
  • 2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propanoylating)
  • 2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)
  • 2-oxobutyrate synthase
  • 2-oxobutyrate-ferredoxin oxidoreductase
  • Alpha-ketobutyrate synthase
  • Alpha-ketobutyrate-ferredoxin oxidoreductase
  • Pyruvate oxidoreductase
  • Pyruvate synthetase
  • Pyruvate:ferredoxin oxidoreductase
  • Pyruvic-ferredoxin oxidoreductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02775
Domain description: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
The deposited structure of PDB entry 6cip contains 6 copies of Pfam domain PF02775 (Thiamine pyrophosphate enzyme, C-terminal TPP binding domain) in Pyruvate:ferredoxin oxidoreductase. Showing 1 copy in chain F.

PF12838
Domain description: 4Fe-4S dicluster domain
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
The deposited structure of PDB entry 6cip contains 6 copies of Pfam domain PF12838 (4Fe-4S dicluster domain) in Pyruvate:ferredoxin oxidoreductase. Showing 1 copy in chain F.

PF10371
Domain description: Domain of unknown function
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
The deposited structure of PDB entry 6cip contains 6 copies of Pfam domain PF10371 (Domain of unknown function) in Pyruvate:ferredoxin oxidoreductase. Showing 1 copy in chain F.

PF01558
Domain description: Pyruvate ferredoxin/flavodoxin oxidoreductase
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
The deposited structure of PDB entry 6cip contains 6 copies of Pfam domain PF01558 (Pyruvate ferredoxin/flavodoxin oxidoreductase) in Pyruvate:ferredoxin oxidoreductase. Showing 1 copy in chain F.

PF17147
Domain description: Pyruvate:ferredoxin oxidoreductase core domain II
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
The deposited structure of PDB entry 6cip contains 6 copies of Pfam domain PF17147 (Pyruvate:ferredoxin oxidoreductase core domain II) in Pyruvate:ferredoxin oxidoreductase. Showing 1 copy in chain F.

PF01855
Domain description: Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
The deposited structure of PDB entry 6cip contains 6 copies of Pfam domain PF01855 (Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg) in Pyruvate:ferredoxin oxidoreductase. Showing 1 copy in chain F.

InterPro InterPro annotations
IPR017896
Domain description: 4Fe-4S ferredoxin-type, iron-sulphur binding domain
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
IPR019456
Domain description: Pyruvate-flavodoxin oxidoreductase, EKR domain
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
IPR002869
Domain description: Pyruvate-flavodoxin oxidoreductase, central domain
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
IPR009014
Domain description: Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
IPR002880
Domain description: Pyruvate flavodoxin/ferredoxin oxidoreductase, pyrimidine binding domain
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
IPR029061
Domain description: Thiamin diphosphate-binding fold
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
IPR011895
Domain description: Pyruvate-flavodoxin oxidoreductase
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
IPR011766
Domain description: Thiamine pyrophosphate enzyme, TPP-binding
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
IPR017900
Domain description: 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
IPR037112
Domain description: Pyruvate-flavodoxin oxidoreductase, EKR domain superfamily
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
IPR019752
Domain description: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase
IPR033412
Domain description: Pyruvate:ferredoxin oxidoreductase, core domain II
Occurring in:
  1. Pyruvate:ferredoxin oxidoreductase

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