EC 2.3.2.27: RING-type E3 ubiquitin transferase
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
- RING E3 ligase
- Ubiquitin transferase RING E3
Protein families (Pfam)![The deposited structure of PDB entry 6cij contains 2 copies of Pfam domain PF13341 (RAG2 PHD domain) in V(D)J recombination-activating protein 2. Showing 1 copy in chain J [auth B] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/6cij_8_B_Pfam_PF13341_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6cij</span> contains 2 copies of Pfam domain <span class='highlight'>PF13341 (RAG2 PHD domain)</span> in <span class='highlight'>V(D)J recombination-activating protein 2</span>. Showing 1 copy in chain <span class='highlight'>J [auth B]</span> (this domain is out of the observed residue ranges!).")
![The deposited structure of PDB entry 6cij contains 2 copies of Pfam domain PF03089 (Recombination activating protein 2) in V(D)J recombination-activating protein 2. Showing 1 copy in chain J [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/6cij_8_B_Pfam_PF03089_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6cij</span> contains 2 copies of Pfam domain <span class='highlight'>PF03089 (Recombination activating protein 2)</span> in <span class='highlight'>V(D)J recombination-activating protein 2</span>. Showing 1 copy in chain <span class='highlight'>J [auth B]</span>.")
![The deposited structure of PDB entry 6cij contains 2 copies of Pfam domain PF12940 (Recombination-activation protein 1 (RAG1), recombinase) in V(D)J recombination-activating protein 1. Showing 1 copy in chain B [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/6cij_1_C_Pfam_PF12940_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6cij</span> contains 2 copies of Pfam domain <span class='highlight'>PF12940 (Recombination-activation protein 1 (RAG1), recombinase)</span> in <span class='highlight'>V(D)J recombination-activating protein 1</span>. Showing 1 copy in chain <span class='highlight'>B [auth C]</span>.")
![The deposited structure of PDB entry 6cij contains 2 copies of Pfam domain PF10426 (Recombination-activating protein 1 zinc-finger domain) in V(D)J recombination-activating protein 1. Showing 1 copy in chain B [auth C] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/6cij_1_C_Pfam_PF10426_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6cij</span> contains 2 copies of Pfam domain <span class='highlight'>PF10426 (Recombination-activating protein 1 zinc-finger domain)</span> in <span class='highlight'>V(D)J recombination-activating protein 1</span>. Showing 1 copy in chain <span class='highlight'>B [auth C]</span> (this domain is out of the observed residue ranges!).")
![The deposited structure of PDB entry 6cij contains 2 copies of Pfam domain PF00097 (Zinc finger, C3HC4 type (RING finger)) in V(D)J recombination-activating protein 1. Showing 1 copy in chain B [auth C] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/6cij_1_C_Pfam_PF00097_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6cij</span> contains 2 copies of Pfam domain <span class='highlight'>PF00097 (Zinc finger, C3HC4 type (RING finger))</span> in <span class='highlight'>V(D)J recombination-activating protein 1</span>. Showing 1 copy in chain <span class='highlight'>B [auth C]</span> (this domain is out of the observed residue ranges!).")
![The deposited structure of PDB entry 6cij contains 1 copy of Pfam domain PF00505 (HMG (high mobility group) box) in High mobility group protein B1. Showing 1 copy in chain G [auth N].](https://www.ebi.ac.uk/pdbe/static/entry/6cij_6_N_Pfam_PF00505_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6cij</span> contains 1 copy of Pfam domain <span class='highlight'>PF00505 (HMG (high mobility group) box)</span> in <span class='highlight'>High mobility group protein B1</span>. Showing 1 copy in chain <span class='highlight'>G [auth N]</span>.")
![The deposited structure of PDB entry 6cij contains 1 copy of Pfam domain PF09011 (HMG-box domain) in High mobility group protein B1. Showing 1 copy in chain G [auth N].](https://www.ebi.ac.uk/pdbe/static/entry/6cij_6_N_Pfam_PF09011_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6cij</span> contains 1 copy of Pfam domain <span class='highlight'>PF09011 (HMG-box domain)</span> in <span class='highlight'>High mobility group protein B1</span>. Showing 1 copy in chain <span class='highlight'>G [auth N]</span>.")
InterPro annotations