› 6cff

X-ray diffraction
2.4Å resolution

Stimulator of Interferon Genes Human

Released:
DOI: 10.2210/pdb6cff/pdb
PDB entry 6cff coloured by chain, front view.
PDB entry 6cff coloured by chain, side view.
PDB entry 6cff coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Ergun SL, Fernandez D, Weiss TM, Li L
Cell 178 290-301.e10 (2019)
PMID: 31230712

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 241 amino acids
Theoretical weight: 27.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 139-379; Coverage: 64%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains: Stimulator of interferon genes protein

Ligands and Environments

1 bound ligand:
Ligand 2BA 1 x 2BA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P41212
Unit cell:
a: 110.93Å b: 110.93Å c: 36.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.193 0.249
Expression system: Escherichia coli

Quick links

Citations

57 review citations

Molecular mechanisms and cellular functions of cGAS-STING signalling.
Hopfner et al. (2020)
56 more

2 mentions without citation

Cyclic di-AMP, a second messenger of primary importance: tertiary structures and binding mechanisms.
He et al. (2020)
1 more