› 6cf4

Electron crystallography
0.75Å resolution

Segment NFGTFS, with familial mutation A315T and phosphorylated threonine, from the low complexity domain of TDP-43, residues 312-317

Released:
DOI: 10.2210/pdb6cf4/pdb
PDB entry 6cf4 coloured by chain, front view.
PDB entry 6cf4 coloured by chain, side view.
PDB entry 6cf4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS
Nat Struct Mol Biol 25 463-471 (2018)
PMID: 29786080
Related structures: EMD-7466

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TAR DNA-binding protein 43 Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 752 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13148 (Residues: 312-317; Coverage: 1%)
Gene names: TARDBP, TDP43

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
Resolution: 0.75Å
Relevant EMDB volumes: EMD-7466
Expression system: Not provided

Quick links

Citations

29 review citations

The molecular language of membraneless organelles.
Gomes et al. (2019)
28 more

4 mentions without citation

How do intrinsically disordered protein regions encode a driving force for liquid-liquid phase separation?
Borcherds et al. (2021)
3 more