6cby

X-ray diffraction
2.55Å resolution

Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975

Released:
Source organism: Homo sapiens
Entry authors: ZENG H, DONG A, Hutchinson A, Seitova A, TATLOCK J, KUMPF R, OWEN A, TAYLOR A, Casimiro-Garcia A, Bountra C, Arrowsmith CH, Edwards AM, BROWN PJ, WU H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-lysine methyltransferase SMYD2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 434 amino acids
Theoretical weight: 49.89 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NRG4 (Residues: 1-433; Coverage: 100%)
Gene names: KMT3C, SMYD2
Sequence domains: SET domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 57.819Å b: 117.579Å c: 65.013Å
α: 90° β: 92.42° γ: 90°
R-values:
R R work R free
0.201 0.199 0.258
Expression system: Spodoptera frugiperda