X-ray diffraction
1.94Å resolution

Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497

Source organism: Homo sapiens
Entry authors: ZENG H, DONG A, Hutchinson A, Seitova A, TATLOCK J, KUMPF R, OWEN A, TAYLOR A, Casimiro-Garcia A, Bountra C, Arrowsmith CH, Edwards AM, BROWN PJ, WU H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
N-lysine methyltransferase SMYD2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 434 amino acids
Theoretical weight: 49.89 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q9NRG4 (Residues: 1-433; Coverage: 100%)
Gene names: KMT3C, SMYD2
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 58.02Å b: 117.031Å c: 64.444Å
α: 90° β: 92.54° γ: 90°
R R work R free
0.181 0.18 0.223
Expression system: Spodoptera frugiperda