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CryoEM structure of human SLC4A4 sodium-coupled acid-base transporter NBCe1

Electron Microscopy
3.9Å resolution
PDB entry 6caa coloured by chain, front view.
PDB entry 6caa coloured by chain, side view.
PDB entry 6caa coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Electrogenic sodium bicarbonate cotransporter 1
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Multimeric state: homo dimer
Accessible surface area: 46818.86 Å2
Buried surface area: 2772.64 Å2
Dissociation area: 1,386.32 Å2
Dissociation energy (ΔGdiss): 11.16 kcal/mol
Dissociation entropy (TΔSdiss): 14.68 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-195385

Macromolecules

Electrogenic sodium bicarbonate cotransporter 1
Chains: A, B
Length: 1035 amino acids
Theoretical weight: 116.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y6R1 (Residues: 77-1079; Coverage: 93%)
Gene names: NBC, NBC1, NBCE1, SLC4A4
Pfam:
InterPro:
Electrogenic sodium bicarbonate cotransporter 1 in PDB entry 6caa, assembly 1, front view.
Electrogenic sodium bicarbonate cotransporter 1 in PDB entry 6caa, assembly 1, side view.
Electrogenic sodium bicarbonate cotransporter 1 in PDB entry 6caa, assembly 1, top view.
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