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Crystal structure of human phosphodiesterase 2A with 1-(2-chloro-5-methoxy-phenyl)-N-isobutyl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide

X-ray diffraction
1.713Å resolution
PDB entry 6c7i coloured by chain, front view.
PDB entry 6c7i coloured by chain, side view.
PDB entry 6c7i coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cGMP-dependent 3',5'-cyclic phosphodiesterase
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Multimeric state: monomeric
Accessible surface area: 16149.02 Å2
Buried surface area: 239.64 Å2
Dissociation area: 73.68 Å2
Dissociation energy (ΔGdiss): 15.87 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126260
Assembly 2
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Assembly Name: cGMP-dependent 3',5'-cyclic phosphodiesterase
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Multimeric state: monomeric
Accessible surface area: 16015.52 Å2
Buried surface area: 240.44 Å2
Dissociation area: 74.04 Å2
Dissociation energy (ΔGdiss): 15.8 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126260
Assembly 3
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Assembly Name: cGMP-dependent 3',5'-cyclic phosphodiesterase
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Multimeric state: monomeric
Accessible surface area: 15526.06 Å2
Buried surface area: 240.14 Å2
Dissociation area: 73.97 Å2
Dissociation energy (ΔGdiss): 15.84 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126260
Assembly 4
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Assembly Name: cGMP-dependent 3',5'-cyclic phosphodiesterase
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Multimeric state: monomeric
Accessible surface area: 15873.8 Å2
Buried surface area: 239.85 Å2
Dissociation area: 74.13 Å2
Dissociation energy (ΔGdiss): 16.88 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126260

Macromolecules

cGMP-dependent 3',5'-cyclic phosphodiesterase
Chains: A, B, C, D
Length: 342 amino acids
Theoretical weight: 39.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00408 (Residues: 579-917; Coverage: 36%)
Gene name: PDE2A
Pfam: 3'5'-cyclic nucleotide phosphodiesterase
InterPro:
CATH: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
cGMP-dependent 3',5'-cyclic phosphodiesterase in PDB entry 6c7i, assembly 1, front view.
cGMP-dependent 3',5'-cyclic phosphodiesterase in PDB entry 6c7i, assembly 1, side view.
cGMP-dependent 3',5'-cyclic phosphodiesterase in PDB entry 6c7i, assembly 1, top view.
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