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Crystal structure of Mycobacterium tuberculosis malate synthase in complex with Methoxynaphthyldiketoacid

Source organism: Mycobacterium tuberculosis
Biochemical function: coenzyme A binding
Biological process: adhesion of symbiont to host
Cellular component: capsule

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EC 2.3.3.9: Malate synthase

Reaction catalysed:
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA
Systematic name:
Acetyl-CoA:glyoxylate C-acetyltransferase ((S)-malate-forming)
Alternative Name(s):
  • Acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolyzing, carboxymethyl-forming)
  • Glyoxylate transacetase
  • Glyoxylate transacetylase
  • Glyoxylic transacetase
  • L-malate glyoxylate-lyase (CoA-acetylating)
  • Malate condensing enzyme
  • Malate synthetase
  • Malic synthetase
  • Malic-condensing enzyme

GO terms

Sequence families

Pfam Protein families (Pfam)
PF20659
Domain description: Malate synthase, C-terminal
Occurring in:
  1. Malate synthase G
The deposited structure of PDB entry 6c7b contains 1 copy of Pfam domain PF20659 (Malate synthase, C-terminal) in Malate synthase G. Showing 1 copy in chain A.

PF01274
Domain description: Malate synthase, TIM barrel domain
Occurring in:
  1. Malate synthase G
The deposited structure of PDB entry 6c7b contains 1 copy of Pfam domain PF01274 (Malate synthase, TIM barrel domain) in Malate synthase G. Showing 1 copy in chain A.

PF20658
Domain description: Malate synthase G, alpha-beta insertion domain
Occurring in:
  1. Malate synthase G
The deposited structure of PDB entry 6c7b contains 1 copy of Pfam domain PF20658 (Malate synthase G, alpha-beta insertion domain) in Malate synthase G. Showing 1 copy in chain A.

PF20656
Domain description: Malate synthase, N-terminal domain
Occurring in:
  1. Malate synthase G
The deposited structure of PDB entry 6c7b contains 1 copy of Pfam domain PF20656 (Malate synthase, N-terminal domain) in Malate synthase G. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006253
Domain description: Malate synthase G
Occurring in:
  1. Malate synthase G
IPR046363
Domain description: Malate synthase, N-terminal and TIM-barrel domains
Occurring in:
  1. Malate synthase G
IPR044856
Domain description: Malate synthase, C-terminal superfamily
Occurring in:
  1. Malate synthase G
IPR001465
Domain description: Malate synthase, TIM barrel domain
Occurring in:
  1. Malate synthase G
IPR011076
Domain description: Malate synthase superfamily
Occurring in:
  1. Malate synthase G

Structure domains

CATH CATH domains
3.20.20.360
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Malate synthase, domain 3
Occurring in:
  1. Malate synthase G
The deposited structure of PDB entry 6c7b contains 1 copy of CATH domain 3.20.20.360 (TIM Barrel) in Malate synthase G. Showing 1 copy in chain A.
1.20.1220.12
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Malate Synthase G; Chain: A; Domain 4
Homology: Malate synthase, domain III
Occurring in:
  1. Malate synthase G
The deposited structure of PDB entry 6c7b contains 1 copy of CATH domain 1.20.1220.12 (Malate Synthase G; Chain: A; Domain 4) in Malate synthase G. Showing 1 copy in chain A.

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