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Crystal Structure of SOCS1 in complex with ElonginB and ElonginC

X-ray diffraction
3.105Å resolution
PDB entry 6c5x coloured by chain, front view.
PDB entry 6c5x coloured by chain, side view.
PDB entry 6c5x coloured by chain, top view.
Source organisms:
Assemblies composition:
hetero tetramer (preferred)
hetero trimer
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 16343.87 Å2
Buried surface area: 4811.29 Å2
Dissociation area: 380.62 Å2
Dissociation energy (ΔGdiss): 4.06 kcal/mol
Dissociation entropy (TΔSdiss): 6.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-111000
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 15981.11 Å2
Buried surface area: 4095.02 Å2
Dissociation area: 996.96 Å2
Dissociation energy (ΔGdiss): 13.93 kcal/mol
Dissociation entropy (TΔSdiss): 11.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-111001

Macromolecules

Elongin-B
Chains: B, E
Length: 118 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15370 (Residues: 1-118; Coverage: 100%)
Gene names: ELOB, TCEB2
Pfam: Ubiquitin family
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Elongin-B in PDB entry 6c5x, assembly 1, front view.
Elongin-B in PDB entry 6c5x, assembly 1, side view.
Elongin-B in PDB entry 6c5x, assembly 1, top view.
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Elongin-C
Chains: C, F
Length: 96 amino acids
Theoretical weight: 10.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15369 (Residues: 17-112; Coverage: 86%)
Gene names: ELOC, TCEB1
Pfam: Skp1 family, tetramerisation domain
InterPro:
CATH: Potassium Channel Kv1.1; Chain A
Elongin-C in PDB entry 6c5x, assembly 1, front view.
Elongin-C in PDB entry 6c5x, assembly 1, side view.
Elongin-C in PDB entry 6c5x, assembly 1, top view.
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suppressor of cytokine signaling 1 L homeolog isoform X1
Chains: A, D
Length: 164 amino acids
Theoretical weight: 18.97 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: C0LEJ4 (Residues: 48-211; Coverage: 78%)
Gene names: SOCS1, cis1, cish1, jab, socs-1, socs1, socs1-a, socs1-b, socs1.L, socs1b, ssi-1, ssi1, tip3
Pfam:
InterPro:
CATH: SOCS box
Suppressor of cytokine signaling 1 L homeolog in PDB entry 6c5x, assembly 1, front view.
Suppressor of cytokine signaling 1 L homeolog in PDB entry 6c5x, assembly 1, side view.
Suppressor of cytokine signaling 1 L homeolog in PDB entry 6c5x, assembly 1, top view.
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Interleukin-6 receptor subunit beta
Chain: G
Length: 10 amino acids
Theoretical weight: 1.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q00560 (Residues: 754-763; Coverage: 1%)
Gene name: Il6st
Interleukin-6 receptor subunit beta in PDB entry 6c5x, assembly 1, front view.
Interleukin-6 receptor subunit beta in PDB entry 6c5x, assembly 1, side view.
Interleukin-6 receptor subunit beta in PDB entry 6c5x, assembly 1, top view.
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