› 6c58

X-ray diffraction
2.2Å resolution

Human UDP-Glucose Dehydrogenase A225L substitutuion with UDP-xylose bound

Released:
DOI: 10.2210/pdb6c58/pdb
PDB entry 6c58 coloured by chain, front view.
PDB entry 6c58 coloured by chain, side view.
PDB entry 6c58 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gross PG, Fallah J, Wood ZA

Function and Biology Details

Reaction catalysed: 
UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130073 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-glucose 6-dehydrogenase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 494 amino acids
Theoretical weight: 55.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60701 (Residues: 1-494; Coverage: 100%)
Gene name: UGDH
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand UDX 10 x UDX
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 93.52Å b: 194.99Å c: 109.54Å
α: 90° β: 110.71° γ: 90°
R-values:
R R work R free
0.212 0.209 0.244
Expression system: Escherichia coli

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