6c42

X-ray diffraction
2Å resolution

Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1156

Released:
Source organism: Homo sapiens
Entry authors: Fanning SW, Hodges-Gallager L, Myles DC, Sun R, Fowler CE, Green BD, Harmon CL, Greene GL, Kushner PJ

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 249 amino acids
Theoretical weight: 28.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 306-554; Coverage: 42%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2
Unit cell:
a: 102.805Å b: 58.016Å c: 87.854Å
α: 90° β: 103.01° γ: 90°
R-values:
R R work R free
0.23 0.228 0.268
Expression system: Escherichia coli