› 6c13

Electron Microscopy
11.33Å resolution

CryoEM structure of mouse PCDH15-4EC-LHFPL5 complex

Released:
DOI: 10.2210/pdb6c13/pdb
PDB entry 6c13 coloured by chain, front view.
PDB entry 6c13 coloured by chain, side view.
PDB entry 6c13 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Ge J, Elferich J, Goehring A, Zhao H, Schuck P, Gouaux E
Elife 7 (2018)
PMID: 30070639
Related structures: EMD-7327

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189382 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Protocadherin-15 Chains: A, B
Molecule details ›
Chains: A, B
Length: 660 amino acids
Theoretical weight: 72.99 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99PJ1 (Residues: 821-1465; Coverage: 34%)
Gene name: Pcdh15
Sequence domains: Cadherin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 11.33Å
Relevant EMDB volumes: EMD-7327
Expression system: Homo sapiens

Quick links

Citations

10 review citations

The Mechanosensory Transduction Machinery in Inner Ear Hair Cells.
Zheng et al. (2021)
9 more

2 mentions without citation

Discoveries in structure and physiology of mechanically activated ion channels.
Kefauver et al. (2020)
1 more