› 6bxx

X-ray diffraction
1.1Å resolution

GYNGFG from low-complexity domain of hnRNPA1, residues 243-248

Released:
DOI: 10.2210/pdb6bxx/pdb
PDB entry 6bxx coloured by chain, front view.
PDB entry 6bxx coloured by chain, side view.
PDB entry 6bxx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks.
Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS
Science 359 698-701 (2018)
PMID: 29439243

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140724 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 614 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09651 (Residues: 243-248; Coverage: 2%)
Gene names: HNRNPA1, HNRPA1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 16.606Å b: 4.769Å c: 40.973Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.064 0.061 0.086
Expression system: Not provided

Quick links

Citations

78 review citations

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates.
Alberti et al. (2019)
77 more

6 mentions without citation

hnRNP A/B Proteins: An Encyclopedic Assessment of Their Roles in Homeostasis and Disease.
Thibault et al. (2021)
5 more