6bty

X-ray diffraction
1.68Å resolution

Crystal structure of the PI3KC2alpha C2 domain in space group P41212

Released:

Function and Biology Details

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 131 amino acids
Theoretical weight: 14.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00443 (Residues: 1559-1686; Coverage: 8%)
Gene name: PIK3C2A
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P41212
Unit cell:
a: 53.062Å b: 53.062Å c: 199.794Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.228
Expression system: Escherichia coli BL21(DE3)