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Crystal structure of the Mucin-1 SEA domain, L1105M mutant, Selenium-derivative

X-ray diffraction
1.6Å resolution
PDB entry 6bsb coloured by chain, front view.
PDB entry 6bsb coloured by chain, side view.
PDB entry 6bsb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mucin-1 subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 6020.51 Å2
Buried surface area: 3982.65 Å2
Dissociation area: 1,991.32 Å2
Dissociation energy (ΔGdiss): 30.61 kcal/mol
Dissociation entropy (TΔSdiss): 10.24 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147558

Macromolecules

Mucin-1 subunit alpha
Chain: A
Length: 57 amino acids
Theoretical weight: 6.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15941 (Residues: 1041-1097; Coverage: 5%)
Gene names: MUC1, PUM
Pfam: SEA domain
InterPro:
Mucin-1 subunit alpha in PDB entry 6bsb, assembly 1, front view.
Mucin-1 subunit alpha in PDB entry 6bsb, assembly 1, side view.
Mucin-1 subunit alpha in PDB entry 6bsb, assembly 1, top view.
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Mucin-1 subunit beta
Chain: B
Length: 55 amino acids
Theoretical weight: 6.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15941 (Residues: 1098-1152; Coverage: 5%)
Gene names: MUC1, PUM
Pfam: SEA domain
InterPro:
CATH: Helix Hairpins
Mucin-1 subunit beta in PDB entry 6bsb, assembly 1, front view.
Mucin-1 subunit beta in PDB entry 6bsb, assembly 1, side view.
Mucin-1 subunit beta in PDB entry 6bsb, assembly 1, top view.
Molecule details ›

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