› 6bqq

X-ray diffraction
1.8Å resolution

Crystal Structure of the Human CAMKK2B in complex with BI2526

Released:
DOI: 10.2210/pdb6bqq/pdb
PDB entry 6bqq coloured by chain, front view.
PDB entry 6bqq coloured by chain, side view.
PDB entry 6bqq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Counago RM, de Souza GP, dos Reis CV, Ramos PZ, Drewry D, Massirer KB, Arruda P, Edwards AM, Elkins JM, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188735 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 33.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RR4 (Residues: 161-449; Coverage: 49%)
Gene names: CAMKK2, CAMKKB, KIAA0787
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand R78 1 x R78
Ligand ACT 3 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P43212
Unit cell:
a: 73.532Å b: 73.532Å c: 119.284Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.191 0.228
Expression system: Escherichia coli

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