PDBe 6bpy

X-ray diffraction
3.2Å resolution

Aspergillus fumigatus Thioredoxin Reductase

Released:
Source organism: Aspergillus fumigatus
Entry authors: Marshall AC, Bruning JB

Function and Biology Details

Reaction catalysed:
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 374 amino acids
Theoretical weight: 39.92 KDa
Source organism: Aspergillus fumigatus
Expression system: Escherichia coli BL21(DE3)
UniProt: Gene names: CDV57_04819, TRR1
Sequence domains: Pyridine nucleotide-disulphide oxidoreductase

Ligands and Environments


Cofactor: Ligand NAP 2 x NAP

Cofactor: Ligand FAD 2 x FAD

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P3221
Unit cell:
a: 159.22Å b: 159.22Å c: 121.37Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.231 0.261
Expression system: Escherichia coli BL21(DE3)