› 6bob

Electron Microscopy
3.9Å resolution

Cryo-EM structure of rat TRPV6* in nanodiscs

Released:
DOI: 10.2210/pdb6bob/pdb
PDB entry 6bob coloured by chain, front view.
PDB entry 6bob coloured by chain, side view.
PDB entry 6bob coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Opening of the human epithelial calcium channel TRPV6.
McGoldrick LL, Singh AK, Saotome K, Yelshanskaya MV, Twomey EC, Grassucci RA, Sobolevsky AI
Nature 553 233-237 (2018)
PMID: 29258289
Related structures: EMD-7123

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 672 amino acids
Theoretical weight: 77.13 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9R186 (Residues: 41-708; Coverage: 87%)
Gene name: Trpv6
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-7123
Expression system: Homo sapiens

Quick links

Citations

34 review citations

Transient Receptor Potential Channels and Calcium Signaling.
Vangeel et al. (2019)
33 more

8 mentions without citation

Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid Ligands.
Salter et al. (2018)
7 more