6bml

X-ray diffraction
2.95Å resolution

Structure of human DHHC20 palmitoyltransferase, irreversibly inhibited by 2-bromopalmitate

Released:

Function and Biology Details

Reaction catalysed:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Palmitoyltransferase ZDHHC20 Chains: A, B
Molecule details ›
Chains: A, B
Length: 295 amino acids
Theoretical weight: 34.6 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q5W0Z9 (Residues: 5-299; Coverage: 81%)
Gene name: ZDHHC20
Sequence domains: DHHC palmitoyltransferase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P63
Unit cell:
a: 99.794Å b: 99.794Å c: 159.947Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.236 0.245
Expression system: Komagataella pastoris