EC 3.6.5.2: Small monomeric GTPase
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)
GO terms
Biochemical function:
Biological process:
- negative regulation of motor neuron apoptotic process
- positive regulation of T cell migration
- regulation of neural precursor cell proliferation
- cellular response to chemokine
- regulation of modification of postsynaptic actin cytoskeleton
- positive regulation of leukocyte adhesion to vascular endothelial cell
- positive regulation of vascular associated smooth muscle contraction
- mitotic cleavage furrow formation
- negative regulation of reactive oxygen species biosynthetic process
- skeletal muscle satellite cell migration
- positive regulation of non-canonical NF-kappaB signal transduction
- regulation of modification of postsynaptic structure
- endothelial tube lumen extension
- motor neuron apoptotic process
- negative regulation of oxidative phosphorylation
- mitotic spindle assembly
- negative regulation of cell migration involved in sprouting angiogenesis
- positive regulation of protein serine/threonine kinase activity
- positive regulation of podosome assembly
- semaphorin-plexin signaling pathway
- cellular response to cytokine stimulus
- cellular response to lipopolysaccharide
- regulation of microtubule cytoskeleton organization
- bone trabecula morphogenesis
- positive regulation of lipase activity
- Wnt signaling pathway, planar cell polarity pathway
- regulation of focal adhesion assembly
- positive regulation of stress fiber assembly
- cell division
- negative chemotaxis
- positive regulation of alpha-beta T cell differentiation
- negative regulation of cell size
- positive regulation of neuron differentiation
- establishment of epithelial cell apical/basal polarity
- wound healing, spreading of cells
- ossification involved in bone maturation
- endothelial cell migration
- beta selection
- apical junction assembly
- stress fiber assembly
- positive regulation of canonical NF-kappaB signal transduction
- odontogenesis
- apolipoprotein A-I-mediated signaling pathway
- cleavage furrow formation
- Roundabout signaling pathway
- substrate adhesion-dependent cell spreading
- cell junction assembly
- regulation of osteoblast proliferation
- negative regulation of intracellular steroid hormone receptor signaling pathway
- regulation of actin cytoskeleton organization
- positive regulation of cytokinesis
- cytoplasmic microtubule organization
- androgen receptor signaling pathway
- regulation of cell migration
- cell differentiation
- actin cytoskeleton organization
- forebrain radial glial cell differentiation
- cerebral cortex cell migration
- substantia nigra development
- cell migration
- regulation of neuron projection development
- negative regulation of cell-substrate adhesion
- skeletal muscle tissue development
- Rho protein signal transduction
- small GTPase-mediated signal transduction
- cell-matrix adhesion
- cell adhesion
- cell cycle
- cytoskeleton organization
- regulation of transcription by RNA polymerase II
- aortic valve formation
- regulation of systemic arterial blood pressure by endothelin
- alpha-beta T cell lineage commitment
- angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
- kidney development
- neuron migration
- cell morphogenesis
Cellular component:
- ficolin-1-rich granule membrane
- glutamatergic synapse
- postsynapse
- cell periphery
- extracellular exosome
- apical junction complex
- dendritic spine
- cell projection
- ruffle membrane
- cleavage furrow
- vesicle
- secretory granule membrane
- midbody
- dendrite
- cell junction
- lamellipodium
- membrane
- cytoplasmic side of plasma membrane
- cell cortex
- focal adhesion
- plasma membrane
- cytoskeleton
- cytosol
- endoplasmic reticulum membrane
- endosome
- cytoplasm
- nucleus
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 6bc0 contains 1 copy of Pfam domain PF00071 (Ras family) in Transforming protein RhoA. Showing 1 copy in chain B [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/6bc0_2_F_Pfam_PF00071_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6bc0</span> contains 1 copy of Pfam domain <span class='highlight'>PF00071 (Ras family)</span> in <span class='highlight'>Transforming protein RhoA</span>. Showing 1 copy in chain <span class='highlight'>B [auth F]</span>.")
InterPro annotations
Structure domains
CATH domains
3.40.50.300
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
P-loop containing nucleotide triphosphate hydrolases
Occurring in:
![The deposited structure of PDB entry 6bc0 contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Transforming protein RhoA. Showing 1 copy in chain B [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/6bc0_2_F_CATH_3.40.50.300_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6bc0</span> contains 1 copy of CATH domain <span class='highlight'>3.40.50.300 (Rossmann fold)</span> in <span class='highlight'>Transforming protein RhoA</span>. Showing 1 copy in chain <span class='highlight'>B [auth F]</span>.")
