X-ray diffraction
4.35Å resolution

The CRAC channel Orai in an unlatched-closed conformation; K163W loss-of-function mutation; P42212 crystal form


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Calcium release-activated calcium channel protein 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 214 amino acids
Theoretical weight: 24.28 KDa
Source organism: Drosophila melanogaster
Expression system: Komagataella pastoris
  • Canonical: Q9U6B8 (Residues: 133-341; Coverage: 60%)
Gene names: CG11430, CRACM1, Orai, olf186-F
Sequence domains: Mediator of CRAC channel activity

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P42212
Unit cell:
a: 118.697Å b: 118.697Å c: 122.419Å
α: 90° β: 90° γ: 90°
R R work R free
0.308 0.306 0.329
Expression system: Komagataella pastoris