› 6bb5

X-ray diffraction
2.28Å resolution

Human Oxy-Hemoglobin

Released:
DOI: 10.2210/pdb6bb5/pdb
PDB entry 6bb5 coloured by chain, front view.
PDB entry 6bb5 coloured by chain, side view.
PDB entry 6bb5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Hemoglobin crystals immersed in liquid oxygen reveal diffusion channels.
Terrell JR, Gumpper RH, Luo M
Biochem Biophys Res Commun 495 1858-1863 (2018)
PMID: 29246762

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159519 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 14.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P69905 (Residues: 3-141; Coverage: 98%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta Chain: B
Molecule details ›
Chain: B
Length: 145 amino acids
Theoretical weight: 15.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P68871 (Residues: 3-147; Coverage: 99%)
Gene name: HBB
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

2 bound ligands:
Ligand HEM 2 x HEM
Ligand OXY 2 x OXY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P41212
Unit cell:
a: 53.73Å b: 53.73Å c: 192.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.205 0.242

Quick links

Citations

4 citation in other articles

Metformin Affects Heme Function as a Possible Mechanism of Action.
Li et al. (2019)
3 more

4 mentions without citation

Enzymatic and non-enzymatic pathways of kynurenines' dimerization: the molecular factors for oxidative stress development.
Zhuravlev et al. (2018)
3 more