6baa

Electron Microscopy
3.63Å resolution

Cryo-EM structure of the pancreatic beta-cell KATP channel bound to ATP and glibenclamide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP-sensitive inward rectifier potassium channel 11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 390 amino acids
Theoretical weight: 43.65 KDa
Source organism: Rattus norvegicus
Expression system: Rattus norvegicus
UniProt:
  • Canonical: P70673 (Residues: 1-390; Coverage: 100%)
Gene name: Kcnj11
Sequence domains:
Structure domains:
ATP-binding cassette sub-family C member 8 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 1582 amino acids
Theoretical weight: 177.33 KDa
Source organism: Cricetus cricetus
Expression system: Rattus norvegicus
UniProt:
  • Canonical: Q09427 (Residues: 1-1582; Coverage: 100%)
Gene names: ABCC8, SUR
Sequence domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.63Å
Relevant EMDB volumes: EMD-7073
Expression system: Rattus norvegicus