6ba5

X-ray diffraction
1.62Å resolution

Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Variable domain of Light Chain, antibody R11 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 114 amino acids
Theoretical weight: 11.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Variable domain Heavy chain, antibody R11 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 117 amino acids
Theoretical weight: 12.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Inactive tyrosine-protein kinase transmembrane receptor ROR1 Chains: M, N, O, P
Molecule details ›
Chains: M, N, O, P
Length: 82 amino acids
Theoretical weight: 9.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01973 (Residues: 311-391; Coverage: 9%)
Gene names: NTRKR1, ROR1
Structure domains: Plasminogen Kringle 4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P1
Unit cell:
a: 58.02Å b: 73.9Å c: 84.12Å
α: 89.86° β: 71.3° γ: 84.49°
R-values:
R R work R free
0.194 0.194 0.214
Expression system: Escherichia coli