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WT Ig-like V Domain with Phosphatidylserine

X-ray diffraction
2.2Å resolution
PDB entry 6b8o coloured by chain, front view.
PDB entry 6b8o coloured by chain, side view.
PDB entry 6b8o coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Triggering receptor expressed on myeloid cells 2
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Multimeric state: homo hexamer
Accessible surface area: 30218.82 Å2
Buried surface area: 15215.45 Å2
Dissociation area: 4,378.59 Å2
Dissociation energy (ΔGdiss): -4.46 kcal/mol
Dissociation entropy (TΔSdiss): 59.45 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-192737

Macromolecules

Triggering receptor expressed on myeloid cells 2
Chains: A, B, C, D, E, F
Length: 169 amino acids
Theoretical weight: 19.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZC2 (Residues: 19-174; Coverage: 74%)
Gene name: TREM2
Pfam: Immunoglobulin V-set domain
InterPro:
CATH: Immunoglobulins
Triggering receptor expressed on myeloid cells 2 in PDB entry 6b8o, assembly 1, front view.
Triggering receptor expressed on myeloid cells 2 in PDB entry 6b8o, assembly 1, side view.
Triggering receptor expressed on myeloid cells 2 in PDB entry 6b8o, assembly 1, top view.
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