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Crystal structure of human DDX19B(AMPPNP)

X-ray diffraction
2.2Å resolution
PDB entry 6b4k coloured by chain, front view.
PDB entry 6b4k coloured by chain, side view.
PDB entry 6b4k coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: ATP-dependent RNA helicase DDX19B
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Multimeric state: monomeric
Accessible surface area: 20468.68 Å2
Buried surface area: 1500.32 Å2
Dissociation area: 112.47 Å2
Dissociation energy (ΔGdiss): -3.77 kcal/mol
Dissociation entropy (TΔSdiss): 1.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193966
Assembly 2 (preferred)
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Assembly Name: ATP-dependent RNA helicase DDX19B
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Multimeric state: monomeric
Accessible surface area: 20823.26 Å2
Buried surface area: 1251.53 Å2
Dissociation area: 127.2 Å2
Dissociation energy (ΔGdiss): -2.45 kcal/mol
Dissociation entropy (TΔSdiss): 1.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193966

Macromolecules

ATP-dependent RNA helicase DDX19B
Chains: A, B
Length: 430 amino acids
Theoretical weight: 48.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UMR2 (Residues: 54-479; Coverage: 89%)
Gene names: DBP5, DDX19, DDX19B, TDBP
Pfam:
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
ATP-dependent RNA helicase DDX19B in PDB entry 6b4k, assembly 2, front view.
ATP-dependent RNA helicase DDX19B in PDB entry 6b4k, assembly 2, side view.
ATP-dependent RNA helicase DDX19B in PDB entry 6b4k, assembly 2, top view.
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