6b4f

X-ray diffraction
2.81Å resolution

Crystal structure of human Gle1 CTD-Nup42 GBM complex

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nucleoporin GLE1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 317 amino acids
Theoretical weight: 36.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53GS7 (Residues: 382-698; Coverage: 45%)
Gene names: GLE1, GLE1L
Sequence domains: GLE1-like protein
Nucleoporin NUP42 Chains: C, D
Molecule details ›
Chains: C, D
Length: 50 amino acids
Theoretical weight: 5.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15504 (Residues: 381-423; Coverage: 10%)
Gene names: CG1, NUP42, NUPL2

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: C2
Unit cell:
a: 164.66Å b: 69.71Å c: 93.57Å
α: 90° β: 90.66° γ: 90°
R-values:
R R work R free
0.247 0.245 0.274
Expression system: Escherichia coli