X-ray diffraction
1.8Å resolution

Function and Biology Details

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Carbapenem-hydrolyzing beta-lactamase KPC Chains: A, B
Molecule details ›
Chains: A, B
Length: 268 amino acids
Theoretical weight: 28.35 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli
  • Canonical: Q9F663 (Residues: 22-289; Coverage: 99%)
Gene names: bla, kpc, kpc1
Sequence domains: Beta-lactamase enzyme family
Structure domains: DD-peptidase/beta-lactamase superfamily

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P1
Unit cell:
a: 34.487Å b: 37.372Å c: 81.831Å
α: 87.78° β: 89.96° γ: 84.53°
R R work R free
0.164 0.162 0.21
Expression system: Escherichia coli