› › Structure analysis

TylHI in complex with native substrate 23-deoxy-5-O-mycaminosyl-tylonolide (23-DMTL)

X-ray diffraction
1.99Å resolution
PDB 6b11 coloured by chain and viewed from the front.
PDB 6b11 coloured by chain and viewed from the side.
PDB 6b11 coloured by chain and viewed from the top.
Source organism: Streptomyces fradiae
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 16000 Å2
Buried surface area: 3800 Å2
Dissociation area: 100 Å2
Dissociation energy (ΔGdiss): -2 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): 11 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 15600 Å2
Buried surface area: 2100 Å2
Dissociation area: 150 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): -15 kcal/mol
Symmetry number: 1

Macromolecules

20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
Chains: A, B
Length: 440 amino acids
Theoretical weight: 47.8 KDa
Source organism: Streptomyces fradiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ZHQ1 (Residues: 1-420; Coverage: 100%)
Gene names: tylH1, tylHI
Pfam: Cytochrome P450
InterPro:
CATH: Cytochrome P450
PDB 6b11 contains 1 copy of 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase in assembly 1. This protein is highlighted and viewed from the front.
PDB 6b11 contains 1 copy of 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase in assembly 1. This protein is highlighted and viewed from the side.
PDB 6b11 contains 1 copy of 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase in assembly 1. This protein is highlighted and viewed from the top.
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