Structure analysis

TylHI in complex with native substrate 23-deoxy-5-O-mycaminosyl-tylonolide (23-DMTL)

X-ray diffraction
1.99Å resolution
Source organism: Streptomyces fradiae
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 16000 Å2
Buried surface area: 3800 Å2
Dissociation area: 100 Å2
Dissociation energy (ΔGdiss): -2 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): 11 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 15600 Å2
Buried surface area: 2100 Å2
Dissociation area: 150 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): -15 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 440 amino acids
Theoretical weight: 47.8 KDa
Source organism: Streptomyces fradiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ZHQ1 (Residues: 1-420; Coverage: 100%)
Gene names: tylH1, tylHI
Pfam: Cytochrome P450
InterPro:
CATH: Cytochrome P450

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