PDBe 6awp

X-ray diffraction
3.8Å resolution

X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the central site

Released:
Source organisms:
Primary publication:
Structural basis for recognition of diverse antidepressants by the human serotonin transporter.
Nat. Struct. Mol. Biol. 25 170-175 (2018)
PMID: 29379174

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Sodium-dependent serotonin transporter Chain: A
Molecule details ›
Chain: A
Length: 549 amino acids
Theoretical weight: 61.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31645 (Residues: 76-618; Coverage: 86%)
Gene names: HTT, SERT, SLC6A4
Sequence domains: Sodium:neurotransmitter symporter family
8B6 antibody FAB heavy chain Chain: B
Molecule details ›
Chain: B
Length: 229 amino acids
Theoretical weight: 24.85 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
8B6 antibody FAB light chain Chain: C
Molecule details ›
Chain: C
Length: 214 amino acids
Theoretical weight: 23.72 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2221
Unit cell:
a: 129.49Å b: 163.86Å c: 140.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.245 0.269
Expression systems:
  • Homo sapiens
  • Spodoptera frugiperda