› 6awh

X-ray diffraction
1.9Å resolution

Staphylococcus aureus Type II pantothenate kinase in complex with ATP and pantothenate analog Deoxy-MeO-N5Pan

Released:
DOI: 10.2210/pdb6awh/pdb
PDB entry 6awh coloured by chain, front view.
PDB entry 6awh coloured by chain, side view.
PDB entry 6awh coloured by chain, top view.
Source organism: Staphylococcus aureus
Entry authors: Chen Y, Antoshchenko T, Strauss E, Barnard L, Huang YH

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Type II pantothenate kinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 266 amino acids
Theoretical weight: 29 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2FWC7 (Residues: 1-266; Coverage: 100%)
Gene names: SAOUHSC_02371, coaA, coaW
Sequence domains: Fumble
Structure domains: Nucleotidyltransferase; domain 5

Ligands and Environments

3 bound ligands:
Ligand ATP 4 x ATP
Ligand MG 4 x MG
Ligand N7G 4 x N7G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 56.776Å b: 136.671Å c: 141.393Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.195 0.226
Expression system: Escherichia coli

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