X-ray diffraction
1.8Å resolution

Crystal structure of SETDB1 Tudor domain with aryl triazole fragments

Source organism: Homo sapiens
Entry authors: MADER P, Mendoza-Sanchez R, IQBAL A, DONG A, DOBROVETSKY E, CORLESS VB, LIEW SK, TEMPEL W, SMIL D, DELA SENA CC, KENNEDY S, DIAZ D, HOLOWNIA A, VEDADI M, BROWN PJ, SANTHAKUMAR V, Bountra C, Edwards AM, YUDIN AK, Arrowsmith CH, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + a [histone H3]-N(6),N(6)-dimethyl-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(9)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Histone-lysine N-methyltransferase SETDB1 Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 24.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q15047 (Residues: 196-402; Coverage: 16%)
Gene names: ESET, KIAA0067, KMT1E, SETDB1
Sequence domains:
Structure domains: SH3 type barrels.

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 55.172Å b: 63.528Å c: 69.987Å
α: 90° β: 90° γ: 90°
R R work R free
0.179 0.179 0.19
Expression system: Escherichia coli