6ath

X-ray diffraction
1.82Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 300 amino acids
Theoretical weight: 34.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains: Transferase(Phosphotransferase) domain 1
Cyclin-A2 Chain: B
Molecule details ›
Chain: B
Length: 263 amino acids
Theoretical weight: 30.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20248 (Residues: 173-432; Coverage: 60%)
Gene names: CCN1, CCNA, CCNA2
Sequence domains:
Structure domains: Cyclin-like
Cyclin-dependent kinase inhibitor 1B Chain: C
Molecule details ›
Chain: C
Length: 68 amino acids
Theoretical weight: 8.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46527 (Residues: 22-85; Coverage: 32%)
Gene names: CDKN1B, KIP1
Sequence domains: Cyclin-dependent kinase inhibitor

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 74.191Å b: 77.645Å c: 137.511Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.171 0.187
Expression system: Escherichia coli