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Cryo-EM structure of CVA10 empty particle

Electron Microscopy
2.7Å resolution
PDB entry 6aku coloured by chain, front view.
PDB entry 6aku coloured by chain, side view.
PDB entry 6aku coloured by chain, top view.
Source organism: Coxsackievirus A10
Assembly composition:
hetero 180-mer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 180-mer
Accessible surface area: 1260133.76 Å2
Buried surface area: 1085473.37 Å2
Dissociation area: 58,608.93 Å2
Dissociation energy (ΔGdiss): 640.41 kcal/mol
Dissociation entropy (TΔSdiss): 218.87 kcal/mol
Symmetry number: 60
PDBe Complex ID: PDB-CPX-101072

Macromolecules

VP1
Chain: A
Length: 298 amino acids
Theoretical weight: 33.23 KDa
Source organism: Coxsackievirus A10
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: W0G0K3 (Residues: 1-298; Coverage: 100%)
Pfam: picornavirus capsid protein
InterPro:
VP1 in PDB entry 6aku, assembly 1, front view.
VP1 in PDB entry 6aku, assembly 1, side view.
VP1 in PDB entry 6aku, assembly 1, top view.
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VP2
Chain: B
Length: 255 amino acids
Theoretical weight: 27.78 KDa
Source organism: Coxsackievirus A10
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: A0A0C5AZ80 (Residues: 70-324; Coverage: 12%)
Pfam: picornavirus capsid protein
InterPro:
CATH: Jelly Rolls
VP2 in PDB entry 6aku, assembly 1, front view.
VP2 in PDB entry 6aku, assembly 1, side view.
VP2 in PDB entry 6aku, assembly 1, top view.
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VP3
Chain: C
Length: 240 amino acids
Theoretical weight: 26.28 KDa
Source organism: Coxsackievirus A10
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: A0A0C5AWF6 (Residues: 325-564; Coverage: 11%)
Pfam: picornavirus capsid protein
InterPro:
CATH: Jelly Rolls
VP3 in PDB entry 6aku, assembly 1, front view.
VP3 in PDB entry 6aku, assembly 1, side view.
VP3 in PDB entry 6aku, assembly 1, top view.
Molecule details ›

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