6aku

Electron Microscopy
2.7Å resolution

Cryo-EM structure of CVA10 empty particle

Released:

Function and Biology Details

Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assemblies composition:
hetero 180-mer (preferred)
hetero trimer
hetero pentadecamer
hetero octadecamer
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Rhv domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.23 KDa
Source organism: Coxsackievirus A10
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: W0G0K3 (Residues: 1-298; Coverage: 100%)
Sequence domains: picornavirus capsid protein
VP2 Chain: B
Molecule details ›
Chain: B
Length: 255 amino acids
Theoretical weight: 27.78 KDa
Source organism: Coxsackievirus A10
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: A0A0C5AZ80 (Residues: 70-324; Coverage: 12%)
Sequence domains: picornavirus capsid protein
VP3 Chain: C
Molecule details ›
Chain: C
Length: 240 amino acids
Theoretical weight: 26.28 KDa
Source organism: Coxsackievirus A10
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: A0A0C5AWF6 (Residues: 325-564; Coverage: 11%)
Sequence domains: picornavirus capsid protein

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-9644
Expression system: Chlorocebus aethiops