6aik

X-ray diffraction
1.83Å resolution

Cab2 mutant H337A complex with phosphopantothenoyl-CMP

Released:

Function and Biology Details

Reaction catalysed:
CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine
Biochemical function:
Biological process:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphopantothenate--cysteine ligase CAB2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 371 amino acids
Theoretical weight: 42.68 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: P40506 (Residues: 1-365; Coverage: 100%)
Gene names: CAB2, YIL083C
Sequence domains: DNA / pantothenate metabolism flavoprotein

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 51.758Å b: 112.513Å c: 55.831Å
α: 90° β: 91.56° γ: 90°
R-values:
R R work R free
0.18 0.178 0.219
Expression system: Escherichia coli