6aak

X-ray diffraction
2.67Å resolution

Crystal structure of JAK3 in complex with peficitinib

Released:
Source organism: Homo sapiens
Entry author: Amano Y

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 287 amino acids
Theoretical weight: 32.86 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P52333 (Residues: 814-1100; Coverage: 26%)
Gene name: JAK3
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P21
Unit cell:
a: 57.076Å b: 114.644Å c: 107.358Å
α: 90° β: 97.65° γ: 90°
R-values:
R R work R free
0.269 0.269 0.326
Expression system: Not provided