6a3v

X-ray diffraction
3.39Å resolution

Complex structure of human 4-1BB and 4-1BBL

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 9 Chains: A, C, E, G, I, K, M, O, Q, S, U, W
Molecule details ›
Chains: A, C, E, G, I, K, M, O, Q, S, U, W
Length: 203 amino acids
Theoretical weight: 21.52 KDa
Source organism: Homo sapiens
Expression system: Baculovirus transfer vector pFASTBAC1
UniProt:
  • Canonical: P41273 (Residues: 58-254; Coverage: 78%)
Gene name: TNFSF9
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 9 Chains: B, D, F, H, J, L, N, P, R, T, V, X
Molecule details ›
Chains: B, D, F, H, J, L, N, P, R, T, V, X
Length: 163 amino acids
Theoretical weight: 17.52 KDa
Source organism: Homo sapiens
Expression system: Baculovirus transfer vector pFASTBAC1
UniProt:
  • Canonical: Q07011 (Residues: 24-180; Coverage: 68%)
Gene names: CD137, ILA, TNFRSF9
Sequence domains: TNFR/NGFR cysteine-rich region

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 126.091Å b: 137.195Å c: 140.318Å
α: 90° β: 111.8° γ: 90°
R-values:
R R work R free
0.265 0.264 0.293
Expression system: Baculovirus transfer vector pFASTBAC1