› 6a03

X-ray diffraction
2.6Å resolution

Structure of pSTING complex

Released:
DOI: 10.2210/pdb6a03/pdb
PDB entry 6a03 coloured by chain, front view.
PDB entry 6a03 coloured by chain, side view.
PDB entry 6a03 coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins.
Cong X, Yuan Z, Du Y, Wu B, Lu D, Wu X, Zhang Y, Li F, Wei B, Li J, Wu J, Xu S, Wang J, Qi J, Shang G, Gu L
J Biol Chem 294 11420-11432 (2019)
PMID: 31167783

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110776 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 201 amino acids
Theoretical weight: 22.83 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: B8XX90 (Residues: 152-342; Coverage: 51%)
Gene names: STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand 2BA 1 x 2BA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 50.517Å b: 80.459Å c: 101.564Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.2 0.257
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Cyclic di-AMP, a second messenger of primary importance: tertiary structures and binding mechanisms.
He et al. (2020)
7 more

3 mentions without citation

The World of Cyclic Dinucleotides in Bacterial Behavior.
Aline Dias da et al. (2020)
2 more