› 6zsq

X-ray diffraction
2Å resolution

Crystal structure of the Cisplatin beta-Lactoglobulin adduct formed after 18 h of soaking

Released:
DOI: 10.2210/pdb6zsq/pdb
PDB entry 6zsq coloured by chain, front view.
PDB entry 6zsq coloured by chain, side view.
PDB entry 6zsq coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Cisplatin binding to β-lactoglobulin: a structural study.
Balasco N, Ferraro G, Loreto D, Iacobucci I, Monti M, Merlino A
Dalton Trans 49 12450-12457 (2020)
PMID: 32852026

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136153 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactoglobulin Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 162 amino acids
Theoretical weight: 18.33 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P02754 (Residues: 17-178; Coverage: 100%)
Gene name: LGB
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family

Ligands and Environments

3 bound ligands:
Ligand NH3 1 x NH3
Ligand PT 3 x PT
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P1
Unit cell:
a: 37.72Å b: 49.05Å c: 49.31Å
α: 69.96° β: 68.59° γ: 77°
R-values:
R R work R free
0.185 0.183 0.224

Quick links

Citations

4 citation in other articles

Protein-Based Delivery Systems for Anticancer Metallodrugs: Structure and Biological Activity of the Oxaliplatin/β-Lactoglobulin Adduct.
Monti et al. (2022)
3 more