› 6ziq

Electron Microscopy
4.33Å resolution

bovine ATP synthase stator domain, state 1

Released:
DOI: 10.2210/pdb6ziq/pdb
PDB entry 6ziq coloured by chain, front view.
PDB entry 6ziq coloured by chain, side view.
PDB entry 6ziq coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structure of the dimeric ATP synthase from bovine mitochondria.
Spikes TE, Montgomery MG, Walker JE
Proc Natl Acad Sci U S A 117 23519-23526 (2020)
PMID: 32900941
Related structures: EMD-11228

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentadecamer (preferred)
PDBe Complex ID:
PDB-CPX-133638 (preferred)
Entry contents:
13 distinct polypeptide molecules
Macromolecules (13 distinct):
ATP synthase protein 8 Chain: 8
Molecule details ›
Chain: 8
Length: 66 amino acids
Theoretical weight: 7.94 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03929 (Residues: 1-66; Coverage: 100%)
Gene names: ATP8, ATPASE8, MT-ATP8, MTATP8
Sequence domains: ATP synthase protein 8
ATP synthase subunit a Chain: a
Molecule details ›
Chain: a
Length: 226 amino acids
Theoretical weight: 24.8 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00847 (Residues: 1-226; Coverage: 100%)
Gene names: ATP6, ATPASE6, MT-ATP6, MTATP6
Sequence domains: ATP synthase A chain
ATP synthase subunit d, mitochondrial Chain: d
Molecule details ›
Chain: d
Length: 160 amino acids
Theoretical weight: 18.59 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13620 (Residues: 2-161; Coverage: 99%)
Gene names: ATP5H, ATP5PD
Sequence domains: ATP synthase D chain, mitochondrial (ATP5H)
ATP synthase subunit e, mitochondrial Chain: e
Molecule details ›
Chain: e
Length: 70 amino acids
Theoretical weight: 8.21 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q00361 (Residues: 2-71; Coverage: 99%)
Gene names: ATP5I, ATP5ME
Sequence domains: ATP synthase E chain
ATP synthase subunit f, mitochondrial Chain: f
Molecule details ›
Chain: f
Length: 87 amino acids
Theoretical weight: 10.18 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q28851 (Residues: 2-88; Coverage: 99%)
Gene names: ATP5J2, ATP5MF
Sequence domains: Mitochondrial F1F0-ATP synthase, subunit f
ATP synthase subunit g, mitochondrial Chain: g
Molecule details ›
Chain: g
Length: 102 amino acids
Theoretical weight: 11.3 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q28852 (Residues: 2-103; Coverage: 99%)
Gene names: ATP5L, ATP5MG
Sequence domains: Mitochondrial ATP synthase g subunit
ATP synthase subunit ATP5MJ, mitochondrial Chain: j
Molecule details ›
Chain: j
Length: 60 amino acids
Theoretical weight: 6.85 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P14790 (Residues: 1-60; Coverage: 100%)
Gene names: ATP5MJ, ATP5MPL, MP68
Sequence domains: Mitochondrial proteolipid
ATP synthase membrane subunit K, mitochondrial Chain: k
Molecule details ›
Chain: k
Length: 57 amino acids
Theoretical weight: 6.31 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q3ZBI7 (Residues: 2-58; Coverage: 98%)
Gene names: ATP5MK, ATPMD, DAPIT, USMG5
Sequence domains: ATP synthase regulation
ATP synthase F(0) complex subunit C1, mitochondrial Chains: M, N, O
Molecule details ›
Chains: M, N, O
Length: 75 amino acids
Theoretical weight: 7.65 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P32876 (Residues: 62-136; Coverage: 55%)
Gene names: ATP5G1, ATP5MC1
Sequence domains: ATP synthase subunit C
ATP synthase F(0) complex subunit B1, mitochondrial Chain: b
Molecule details ›
Chain: b
Length: 214 amino acids
Theoretical weight: 24.7 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13619 (Residues: 43-256; Coverage: 84%)
Gene names: ATP5F, ATP5F1, ATP5PB
Sequence domains: Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
ATP synthase-coupling factor 6, mitochondrial Chain: h
Molecule details ›
Chain: h
Length: 76 amino acids
Theoretical weight: 8.97 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P02721 (Residues: 33-108; Coverage: 70%)
Gene names: ATP5J, ATP5PF
Sequence domains: Mitochondrial ATP synthase coupling factor 6
ATP synthase subunit O, mitochondrial Chain: S
Molecule details ›
Chain: S
Length: 190 amino acids
Theoretical weight: 20.96 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13621 (Residues: 24-213; Coverage: 89%)
Gene names: ATP5O, ATP5PO
Sequence domains: ATP synthase delta (OSCP) subunit
ATP synthase subunit alpha, mitochondrial Chain: C
Molecule details ›
Chain: C
Length: 510 amino acids
Theoretical weight: 55.33 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P19483 (Residues: 44-553; Coverage: 92%)
Gene names: ATP5A1, ATP5A2, ATP5F1A
Sequence domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand M3L 3 x M3L

Experiments and Validation Details

Entry percentile scores
Resolution: 4.33Å
Relevant EMDB volumes: EMD-11228

Quick links

Citations

39 review citations

The mitochondrial permeability transition: Recent progress and open questions.
Bernardi et al. (2022)
38 more